Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments-Reference-Cited by-同舟云学术

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Published:2008-06 Issue:11 Volume:18 Page:3446-3455
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Li Lian-Sheng,Zhou Yuefen,Murphy Douglas E.,Stankovic Nebojsa,Zhao Jingjing,Dragovich Peter S.,Bertolini Thomas,Sun Zhongxiang,Ayida Benjamin,Tran Chinh V.,Ruebsam Frank,Webber Stephen E.,Shah Amit M.,Tsan Mei,Showalter Richard E.,Patel Rupal,LeBrun Laurie A.,Bartkowski Darian M.,Nolan Thomas G.,Norris Daniel A.,Kamran Ruhi,Brooks Jennifer,Sergeeva Maria V.,Kirkovsky Leo,Zhao Qiang,Kissinger Charles R.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

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4. Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

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