Discovery of highly potent and selective type I B-Raf kinase inhibitors-Reference-Cited by-同舟云学术

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Discovery of highly potent and selective type I B-Raf kinase inhibitors

Published:2009-12 Issue:23 Volume:19 Page:6571-6574
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Wang Xiaolun,Berger Dan M.,Salaski Edward J.,Torres Nancy,Hu Yongbo,Levin Jeremy I.,Powell Dennis,Wojciechowicz Donald,Collins Karen,Frommer Eileen

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. The RAF proteins take centre stage

2. Mutations of the BRAF gene in human cancer

3. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

4. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase

5. Demonstration of a Genetic Therapeutic Index for Tumors Expressing OncogenicBRAFby the Kinase Inhibitor SB-590885

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