Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity-Reference-Cited by-同舟云学术

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Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: Dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity

Published:2009-12 Issue:24 Volume:19 Page:6855-6861
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Chowdhury Morshed A.,Abdellatif Khaled R.A.,Dong Ying,Das Dipankar,Yu Gang,Velázquez Carlos A.,Suresh Mavanur R.,Knaus Edward E.

Funder

Canadian Institutes of Health Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference48 articles.

1. The Salicylates,1966

2. Novel analgesic-antiinflammatory salicylates

3. The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

4. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

5. Reduced Risk of Upper Gastrointestinal Ulcer Complications With Celecoxib, A Novel Cox-2 Inhibitor

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