2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2-Reference-Cited by-同舟云学术

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

Published:2009-12 Issue:23 Volume:19 Page:6529-6533
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ledeboer Mark W.,Pierce Albert C.,Duffy John P.,Gao Huai,Messersmith David,Salituro Francesco G.,Nanthakumar Suganthini,Come Jon,Zuccola Harmon J.,Swenson Lora,Shlyakter Dina,Mahajan Sudipta,Hoock Thomas,Fan Bin,Tsai Wan-Jung,Kolaczkowski Elaine,Carrier Scott,Hogan James K.,Zessis Richard,Pazhanisamy S.,Bennani Youssef L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

1. The World Health Organization (WHO) classification of the myeloid neoplasms

2. JAKS AND STATS: Biological Implications

3. The JAK kinases: Not just another kinase drug discovery target

4. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera

5. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

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