Novel selective human melanocortin-3 receptor ligands: Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold-Reference-Cited by-同舟云学术

Novel selective human melanocortin-3 receptor ligands: Use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold

Published:2007-05 Issue:9 Volume:17 Page:2492-2498
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ballet Steven,Mayorov Alexander V.,Cai Minying,Tymecka Dagmara,Chandler Kevin B.,Palmer Erin S.,Rompaey Karolien Van,Misicka Aleksandra,Tourwé Dirk,Hruby Victor J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference37 articles.

1. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors

2. Exploring the Stereostructural Requirements of Peptide Ligands for the Melanocortin Receptors

3. Melanocortin ligands: 30 years of structure-activity relationship (SAR) studies

4. Role of melanocortins in the central control of feeding

5. Early Leptin Response to a Palatable Diet Predicts Dietary Obesity in Rats: Key Role of Melanocortin-4 Receptors in the Ventromedial Hypothalamic Nucleus

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1. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH₂ Lead to Potent and Selective Agonists at hMC1R and hMC4R;Journal of Medicinal Chemistry;2023-05-03

2. Targeting Melanocortin Receptors Using S_NAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates;J MED CHEM;2023

3. Targeting Melanocortin Receptors Using S_NAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates;Journal of Medicinal Chemistry;2023-02-21

4. Demonstration of a Common DPhe⁷ to DNal(2′)⁷ Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides;Journal of Medicinal Chemistry;2022-04-11

5. Demonstration of a common DPhe⁷ to DNal(2’)⁷ peptide ligand antagonist switch for the melanocortin-3 and melanocortin-4 receptors identifies systematic mischaracterization of the pharmacological properties of melanocortin peptides;2022-01-03