Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors-Reference-Cited by-同舟云学术

Synthesis and SAR of new pyrazolo[4,3-h]quinazoline-3-carboxamide derivatives as potent and selective MPS1 kinase inhibitors

Published:2011-08 Issue:15 Volume:21 Page:4507-4511
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Caldarelli Marina,Angiolini Mauro,Disingrini Teresa,Donati Daniele,Guanci Marco,Nuvoloni Stefano,Posteri Helena,Quartieri Francesca,Silvagni Marco,Colombo Riccardo

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

2. Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

3. Release of Mps1 from kinetochores is crucial for timely anaphase onset

4. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

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