Discovery of biaryls as RORγ inverse agonists by using structure-based design-Reference-Cited by-同舟云学术

Discovery of biaryls as RORγ inverse agonists by using structure-based design

Published:2016-05 Issue:10 Volume:26 Page:2459-2463
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Enyedy Istvan J.^ORCID,Powell Noel A.,Caravella Justin,van Vloten Kurt,Chao Jianhua,Banerjee Daliya,Marcotte Douglas,Silvian Laura,McKenzie Andres,Hong Victor Sukbong,Fontenot Jason D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

2. The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

3. Targeting IL-17 and TH17 cells in chronic inflammation

4. Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc)

5. A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

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