Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine-Reference-Cited by-同舟云学术

Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine

Published:2016-07 Issue:13 Volume:26 Page:3202-3206
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Koltun Dmitry O.,Parkhill Eric Q.,Elzein Elfatih,Kobayashi Tetsuya,Notte Gregory T.,Kalla Rao,Jiang Robert H.,Li Xiaofen,Perry Thao D.,Avila Belem,Wang Wei-Qun,Smith-Maxwell Catherine,Dhalla Arvinder K.,Rajamani Sridharan,Stafford Brian,Tang Jennifer,Mollova Nevena,Belardinelli Luiz,Zablocki Jeff A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

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2. Kochanek, K. D.; Xu, J.; Murphy, S. L.; Minin, A.O.; Kung, H. C. National Vital Statistics Report 2012, 60, 1.

3. The Usefulness of Ranolazine for the Treatment of Refractory Chronic Stable Angina Pectoris as Determined from a Systematic Review of Randomized Controlled Trials

4. Pathophysiology and pharmacology of the cardiac “late sodium current”

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