Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6)-Reference-Cited by-同舟云学术

Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6)

Published:2018-07 Issue:12 Volume:28 Page:2222-2227
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Motoyama Keisuke^ORCID,Nagata Tsutomu,Kobayashi Jun,Nakamura Akifumi,Miyoshi Naoki,Kazui Miho,Sakurai Ken,Sakakura Tomoko

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction

2. Transient Receptor Potential Channels as Drug Targets: From the Science of Basic Research to the Art of Medicine

3. TRP-ing up Heart and Vessels: Canonical Transient Receptor Potential Channels and Cardiovascular Disease

4. TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

5. A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis

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