Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy-Reference-Cited by-同舟云学术

Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy

Published:2014-06 Issue:12 Volume:24 Page:2648-2650
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Li Jin,Wu Yuelin,Guo Zizhao,Zhuang Chunlin,Yao Jianzhong,Dong Guoqiang,Yu Zhiliang,Min Xiao,Wang Shengzheng,Liu Yang,Wu Shanchao,Zhu Shiping,Sheng Chunquan,Miao Zhenyuan,Zhang Wannian

Funder

National Natural Science Foundation of China

Bio-Pharmaceutical Project of Science and Technology of Shanghai

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

2. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

3. Mdm2 promotes the rapid degradation of p53

4. Awakening guardian angels: drugging the p53 pathway

5. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

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