Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency-Reference-Cited by-同舟云学术

Discovery and SAR of a novel series of metabotropic glutamate receptor 5 positive allosteric modulators with high ligand efficiency

Published:2014-08 Issue:15 Volume:24 Page:3641-3646
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Turlington Mark,Noetzel Meredith J.,Bridges Thomas M.,Vinson Paige N.,Steckler Thomas,Lavreysen Hilde,Mackie Claire,Bartolomé-Nebreda José M.,Conde-Ceide Susana,Tong Han Min,Macdonald Gregor J.,Daniels J. Scott,Jones Carrie K.,Niswender Colleen M.,Conn P. Jeffrey,Lindsley Craig W.,Stauffer Shaun R.

Funder

Janssen

Pharmaceutical Companies of Johnson & Johnson

NIH

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

2. Discovery of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 (mGluR5)

3. Novel Potential Therapeutics for Schizophrenia: Focus on the Modulation of Metabotropic Glutamate Receptor Function

4. Metabotropic Glutamate Receptors: Potential Drug Targets for the Treatment of Schizophrenia

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