3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead

Author:

Soth Michael,Abbot Sarah,Abubakari Allassan,Arora Nidhi,Arzeno Humberto,Billedeau Roland,Dewdney Nolan,Durkin Kieran,Frauchiger Sandra,Ghate Manjiri,Goldstein David M.,Hill Ronald J.,Kuglstatter Andreas,Li Fujun,Loe Brad,McCaleb Kristen,McIntosh Joel,Papp Eva,Park Jaehyeon,Stahl Martin,Sung Man-Ling,Suttman Rebecca,Swinney David C.,Weller Paul,Wong Brian,Zecic Hasim,Gabriel Tobias

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. The p38 mitogen-activated protein kinase (MAPK) pathway in rheumatoid arthritis

2. Pathway to the Clinic: Inhibition of P38 MAP Kinase. A Review of Ten Chemotypes Selected for Development

3. p38 Mitogen-Activated Protein Kinase (MAPK) in Rheumatoid Arthritis

4. Selective p38α Inhibitors Clinically Evaluated for the Treatment of Chronic Inflammatory Disorders

5. Genovese, M. C.; Gao, L.; Yin, J.; Smith, S.; Weinblatt, M.; Smolen, J.; Wang, X.; Schieven, G.; Garcia-Meijide, J. A.; Latek, R.; Pasternak, R.; Kaul, S.; Roy, A.; Raymond, R., Thienel, U.; Wang, J. Presented at the American College of Rheumatology Scientific Meeting; Atlanta, GA, 2010; Poster 1119.

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