Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain-Reference-Cited by-同舟云学术

Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain

Published:2010-06 Issue:12 Volume:20 Page:3760-3763
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Colucci John,Boyd Michael,Berthelette Carl,Chiasson Jean-Francois,Wang Zhaoyin,Ducharme Yves,Friesen Rick,Wrona Mark,Levesque Jean-Francois,Denis Danielle,Mathieu Marie-Claude,Stocco Rino,Therien Alex G.,Clarke Patsy,Rowland Steve,Xu Daigen,Han Yongxin

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. The development of COX2 inhibitors

2. The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis

3. Prostaglandin E2 Receptor EP4 Contributes to Inflammatory Pain Hypersensitivity

4. MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a Selective E Prostanoid Receptor 4 Antagonist, Relieves Joint Inflammation and Pain in Rodent Models of Rheumatoid and Osteoarthritis

5. Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4;Pharmacological Reviews;2024-03-04

2. Green Approach toward Triazole forming Reactions for Developing Anticancer Drugs;Current Organic Synthesis;2023-05-08

3. Synthesis, anti-cancer activity and molecular docking studies of new nicotinamide containing EP4 antagonists;Journal of Molecular Structure;2022-07

4. Scaffold Hopping Strategy to Identify Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy;Journal of Medicinal Chemistry;2022-05-31

5. Rhodium-Catalyzed C–H Activation of Indoles for the Construction of Spiroindole Scaffolds;Synthesis;2022-03-08