Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability-Reference-Cited by-同舟云学术

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Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability

Published:2022-04 Issue: Volume:61 Page:128625
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Tian Yuan,Lahue Brian R.,Ma Yao,Nair Latha G.,Pan Weidong,Doll Ronald J.,Guzi Timothy,Ma Yao,Wang Yaolin,Bogen Stéphane L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. (a) Vousden KH, Ryan KM. Nature Review Cancer 2009, 9, 691 and the references therein

2. (b) Levine AJ, Oren M. Nature Reviews Cancer 2009, 9, 749 and the references therein.

3. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

4. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

5. mdm2 expression is induced by wild type p53 activity.

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