Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays-Reference-Cited by-同舟云学术

Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine—a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays

Published:2007-02 Issue:3 Volume:17 Page:602-608
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Noronha Glenn,Barrett Kathy,Boccia Antonio,Brodhag Tessa,Cao Jianguo,Chow Chun P.,Dneprovskaia Elena,Doukas John,Fine Richard,Gong Xianchang,Gritzen Colleen,Gu Hong,Hanna Ehab,Hood John D.,Hu Steven,Kang Xinshan,Key Jann,Klebansky Boris,Kousba Ahmed,Li Ge,Lohse Dan,Mak Chi Ching,McPherson Andrew,Palanki Moorthy S.S.,Pathak Ved P.,Renick Joel,Shi Feng,Soll Richard,Splittgerber Ute,Stoughton Silva,Tang Suhan,Yee Shiyin,Zeng Binqi,Zhao Ningning,Zhu Hong

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. Src Inhibitors as Potential Therapeutic Agents for Human Cancers

2. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

3. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction

4. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke

5. Src inhibitors: drugs for the treatment of osteoporosis, cancer or both?

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