Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1-Reference-Cited by-同舟云学术

Aminoimidazoles as bioisosteres of acylguanidines: novel, potent, selective and orally bioavailable inhibitors of the sodium hydrogen exchanger isoform-1

Published:2004-01 Issue:1 Volume:14 Page:177-180
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ahmad Saleem,Ngu Khehyong,Combs Donald W,Wu Shung C,Weinstein David S,Liu Wen,Chen Bang-Chi,Chandrasena Gamini,Dorso Charles R,Kirby Mark,Atwal Karnail S

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. Primary structure and functional expression of a novel gastrointestinal isoform of the rat Na/H exchanger

2. Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.

3. Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

4. Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

5. A unique sodium-hydrogen exchange isoform (NHE-4) of the inner medulla of the rat kidney is induced by hyperosmolarity.

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