Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK-Reference-Cited by-同舟云学术

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK

Published:2016-08 Issue:15 Volume:26 Page:3562-3566
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Laufer Radoslaw,Li Sze-Wan,Liu Yong,Ng Grace,Lang Yunhui,Feher Miklos,Brokx Richard,Beletskaya Irina,Hodgson Richard,Mao Guodong,Plotnikova Olga,Awrey Donald E.,Mason Jacqueline M.,Wei Xin,Lin Dan Chi-Chia,Che Yi,Kiarash Reza,Madeira Brian,Fletcher Graham C.,Mak Tak W.,Bray Mark R.,Pauls Henry W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. The MPS1 Family of Protein Kinases

2. Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint

3. Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

4. Genetic instability in colorectal cancers

5. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

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