Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors-Reference-Cited by-同舟云学术

Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors

Published:2007-06 Issue:12 Volume:17 Page:3463-3467
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Alam Mahbub,Beevers Rebekah E.,Ceska Tom,Davenport Richard J.,Dickson Karen M.,Fortunato Mara,Gowers Lewis,Haughan Alan F.,James Lynwen A.,Jones Mark W.,Kinsella Natasha,Lowe Christopher,Meissner Johannes W.G.,Nicolas Anne-Lise,Perry Benjamin G.,Phillips David J.,Pitt William R.,Platt Adam,Ratcliffe Andrew J.,Sharpe Andrew,Tait Laura J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2. Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

3. Selective interaction of JNK protein kinase isoforms with transcription factors.

4. Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential

5. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

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