Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis-Reference-Cited by-同舟云学术

Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis

Published:2007-05 Issue:10 Volume:17 Page:2723-2727
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Gomez Laurent,Hack Michael D.,Wu Jiejun,Wiener John J.M.,Venkatesan Hari,Santillán Alejandro,Pippel Daniel J.,Mani Neelakandha,Morrow Brian J.,Motley S. Timothy,Shaw Karen Joy,Wolin Ronald,Grice Cheryl A.,Jones Todd K.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones

2. Pyridonecarboxylic acids as antibacterial agents. Part 14. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency

3. Emergence of Fluoroquinolone Resistance among Multiply Resistant Strains of Streptococcus pneumoniae in Hong Kong

4. Methicillin-ResistantStaphylococcus aureus in Europe

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