Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity-Reference-Cited by-同舟云学术

Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity

Published:2010-04 Issue:8 Volume:20 Page:2591-2596
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xu Ruo,Cole David,Asberom Ted,Bara Tom,Bennett Chad,Burnett Duane A.,Clader John,Domalski Martin,Greenlee William,Hyde Lynn,Josien Hubert,Li Hongmei,McBriar Mark,McKittrick Brian,McPhail Andrew T.,Pissarnitski Dmitri,Qiang Li,Rajagopalan Murali,Sasikumar Thavalakulamgar,Su Jing,Tang Haiqun,Wu Wen-Lian,Zhang Lili,Zhao Zhiqiang

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2. The molecular pathology of Alzheimer's disease

3. Alzheimer's Disease: The Amyloid Cascade Hypothesis

4. Views on Amyloid Hypothesis and Secretase Inhibitors for Treating Alzheimers Disease: Progress and Problems

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