Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates-Reference-Cited by-同舟云学术

Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

Published:2006-07 Issue:14 Volume:16 Page:3813-3816
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Takahashi Yasuko,Fuwa Haruhiko,Kaneko Akane,Sasaki Makoto,Yokoshima Satoshi,Koizumi Hifumi,Takebe Tohru,Kan Toshiyuki,Iwatsubo Takeshi,Tomita Taisuke,Natsugari Hideaki,Fukuyama Tohru

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Alzheimer's Disease: Genes, Proteins, and Therapy

2. The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease

3. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

4. Studies of Aβ Pharmacodynamics in the Brain, Cerebrospinal Fluid, and Plasma in Young (Plaque-Free) Tg2576 Mice Using the γ-Secretase Inhibitor N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575)

5. Quantitative Measurement of Changes in Amyloid-β(40) in the Rat Brain and Cerebrospinal Fluid following Treatment with the γ-Secretase Inhibitor LY-411575 [N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-l-alaninamide]

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