Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9-Reference-Cited by-同舟云学术

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Identification of potent 5-pyrimidinyl-2-aminothiazole CDK4, 6 inhibitors with significant selectivity over CDK1, 2, 5, 7, and 9

Published:2006-07 Issue:14 Volume:16 Page:3751-3754
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Shimamura Tadashi,Shibata Jun,Kurihara Hideki,Mita Takashi,Otsuki Sachie,Sagara Takeshi,Hirai Hiroshi,Iwasawa Yoshikazu

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Cancer Cell Cycles

2. Cyclins and Cyclin-Dependent Kinases: Theme and Variations

3. CDK inhibitors: positive and negative regulators of G1-phase progression

4. The regulation of E2F by pRB-family proteins

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