A small molecule inhibitor of p53-inducible protein phosphatase PPM1D-Reference-Cited by-同舟云学术

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A small molecule inhibitor of p53-inducible protein phosphatase PPM1D

Published:2012-01 Issue:1 Volume:22 Page:729-732
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Yagi Hiroaki,Chuman Yoshiro,Kozakai Yuuki,Imagawa Toshiaki,Takahashi Yu,Yoshimura Fumihiko,Tanino Keiji,Sakaguchi Kazuyasu

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

2. p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

3. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

4. Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

5. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK–mediated activation of the p16Ink4a-p19Arf pathway

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1. A comprehensive overview of PPM1B: From biological functions to diseases;European Journal of Pharmacology;2023-05

2. Alkyl-substituted N-methylaryl-N′-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase;European Journal of Medicinal Chemistry;2022-12

3. Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen;ACS Pharmacology & Translational Science;2022-09-28

4. Development of Antibody-like Proteins Targeting the Oncogenic Ser/Thr Protein Phosphatase PPM1D;Processes;2022-07-29

5. The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?;Biochemical Journal;2022-07-29

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