p38 MAP kinase inhibitors. Part 5: Discovery of an orally bio-available and highly efficacious compound based on the 7-amino-naphthyridone scaffold

Author:

Natarajan Swaminathan R.,Liu Luping,Levorse Mark,Thompson James E.,O’Neill Edward A.,O’Keefe Stephen J.,Vora Kalpit A.,Cvetovich Raymond,Chung John Y.,Carballo-Jane Ester,Visco Denise M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference7 articles.

1. p38MAP kinase inhibitors. part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold

2. Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase

3. Natarajan, S. R.; Wisnoski, D. D.; Thompson, J. E.; O’Neill, E. A.; O’Keefe, S. J.; Zaller, D. M.; Doherty, J. B. Bioorg. Med. Chem. Lett. 2, in press.

4. Bemis, G. W.; Salituro, F. G.; Duffy, J. P.; Harrington, E. M. U.S. Patent 2000, 6,147,080.

5. p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones

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