Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)-Reference-Cited by-同舟云学术

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious γ-secretase inhibitors (Part II)

Published:2010-06 Issue:12 Volume:20 Page:3502-3506
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Ye Xiaocong M.,Konradi Andrei W.,Smith Jenifer,Aubele Danielle L.,Garofalo Albert W.,Marugg Jennifer,Neitzel Marty L.,Semko Chris M.,Sham Hing L.,Sun Minghua,Truong Anh P.,Wu Jing,Zhang Hongbin,Goldbach Erich,Sauer John-Michael,Brigham Elizabeth F.,Bova Michael,Basi Guriqbal S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

2. Secretase Targets for Alzheimer's Disease: Identification and Therapeutic Potential

3. Notch regulation of lymphocyte development and function

4. Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

5. Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

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