Discovery of nonpeptide 3,4-dihydroquinazoline-4-carboxamides as potent and selective sst2 agonists

Author:

Zhao Jian,Wang Shimiao,Han Sangdon,Kim Sun Hee,Kusnetzow Ana Karin,Nguyen Julie,Rico-Bautista Elizabeth,Tan Hannah,Betz Stephen F.,Scott Struthers R.,Zhu Yunfei

Funder

National Institutes of Health

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Somatostatin receptors: from signaling to clinical practice;Theodoropoulou;Front Neuroendocrinol,2013

2. Opportunities in somatostatin research: biological, chemical and therapeutic aspects;Weckbecker;Nat Rev Drug Discovery,2003

3. Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors;Wolkenberg;Curr Opin Drug Discov Devel,2008

4. Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells;Parmar;Biochem Biophys Res Commun,1999

5. Acromegaly;Chanson;Orphanet J Rare Dis,2008

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