Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference21 articles.
1. Localization of a family of muscarinic receptor mRNAs in rat brain
2. Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice
3. Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus
4. M 1 -M 5 Muscarinic Receptor Knockout Mice as Novel Tools to Study the Physiological Roles of the Muscarinic Cholinergic System
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1. Moving from cells to animals: challenges of studying allosteric modulators in vivo;Allosteric Modulation of G Protein-Coupled Receptors;2022
2. Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias;Frontiers in Pharmacology;2021-01-29
3. Selective Positive Allosteric Modulation for the M1 Muscarinic Receptor: discovery and development of compound VU0486846 and its importance for the development of treatments for Alzheimer's and Schizophrenia;ARS PHARM;2021
4. Allosteric Modulation;Reference Module in Biomedical Sciences;2021
5. Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases;Journal of Medicinal Chemistry;2019-02-05
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