Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity-Reference-Cited by-同舟云学术

Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity

Published:2019-02 Issue:4 Volume:29 Page:563-569
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Varano Flavia,Catarzi Daniela^ORCID,Falsini Matteo,Dal Ben Diego^ORCID,Buccioni Michela,Marucci Gabriella,Volpini Rosaria^ORCID,Colotta Vittoria^ORCID

Funder

University of Florence

Italian Ministry for University and Research

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference42 articles.

1. Pharmacology of adenosine receptors: the state of the art;Borea;Physiol Rev,2018

2. Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?;Borea;Trends Pharmacol Sci,2016

3. Adenosine receptors in health and disease;Gessi;Adv Pharmacol,2011

4. Biochemical and pharmacological role of A1 adenosine receptors and their modulation as novel therapeutic strategy;Varani;Adv Exp Med Biol Protein Rev,2017

5. Cardio-renal effects of the A1 adenosine receptor antagonist SVL320 in patients with heart failure;Mitrovic;Circ Heart Fail,2009

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4. Design and synthesis of novel urea derivatives of pyrimidine-pyrazoles as anticancer agents;Journal of Molecular Structure;2022-03

5. Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression;Pharmaceuticals;2021-07-09