Discovery of potent and selective PKC-θ inhibitors-Reference-Cited by-同舟云学术

Discovery of potent and selective PKC-θ inhibitors

Published:2007-01 Issue:1 Volume:17 Page:225-230
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cywin Charles L.,Dahmann Georg,Prokopowicz Anthony S.,Young Erick R.R.,Magolda Ronald L.,Cardozo Mario G.,Cogan Derek A.,DiSalvo Darren,Ginn John D.,Kashem Mohammed A.,Wolak John P.,Homon Carol A.,Farrell Thomas M.,Grbic Heather,Hu Hanbo,Kaplita Paul V.,Liu Lisa H.,Spero Denice M.,Jeanfavre Deborah D.,O’Shea Kathy M.,White Della M.,Woska Joseph R.,Brown Maryanne L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference12 articles.

1. Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

2. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

3. Three-dimensional segregation of supramolecular activation clusters in T cells

4. Selective modulation of protein kinase C-Θ during T-cell activation

5. Heat maps were prepared using Spotfire® Decision Site 8.2® from Spotfire, Inc., 212 Elm St., Somerville, MA, 02144 USA.

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