Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A-Reference-Cited by-同舟云学术

Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A

Published:2006-12 Issue:24 Volume:16 Page:6306-6309
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Honda Tadashi,Liby Karen T.,Su Xiaobo,Sundararajan Chitra,Honda Yukiko,Suh Nanjoo,Risingsong Renee,Williams Charlotte R.,Royce Darlene B.,Sporn Michael B.,Gribble Gordon W.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Triterpenoid Extractives in the Outer Bark ofBetula lenta(Black Birch)

2. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

3. Betulinic acid induces apoptosis in human neuroblastoma cell lines

4. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells

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