Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor-Reference-Cited by-同舟云学术

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

Published:2012-08 Issue:15 Volume:22 Page:5084-5088
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Salovich James M.,Vinson Paige N.,Sheffler Douglas J.,Lamsal Atin,Utley Thomas J.,Blobaum Anna L.,Bridges Thomas M.,Le Uyen,Jones Carrie K.,Wood Michael R.,Scott Daniels J.,Jeffrey Conn P.,Niswender Colleen M.,Lindsley Craig W.,Hopkins Corey R.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Nicotinic Acetylcholine Receptors and Nicotinic Cholinergic Mechanisms of the Central Nervous System

2. Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

3. Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse, and Parkinson’s Disease

4. Muscarinic Acetylcholine Receptor Knockout Mice: Novel Phenotypes and Clinical Implications

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