IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: Improved PK, hERG and metabolic profiles-Reference-Cited by-同舟云学术

IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: Improved PK, hERG and metabolic profiles

Published:2014-02 Issue:4 Volume:24 Page:1085-1088
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Nair Anilkumar G.,Wong Michael K.C.,Shu Youheng,Jiang Yueheng,Jenh Chung-Her,Kim Seong Heon,Yang De-Yi,Zeng Qingbei,Shao Yuefei,Zawacki Lisa Guise,Duo Jingqi,McGuinness Brian F.,Carroll Carolyn DiIanni,Hobbs Doug W.,Shih Neng-Yang,Rosenblum Stuart B.,Kozlowski Joseph A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference26 articles.

1. CXCR3, Inflammation, and Autoimmune Diseases

2. Cytokines: Principles and prospects

3. Chemokines and leukocyte traffic

4. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

5. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes.

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