Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Structure–activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4′ and C6 variations

Published:2023-07 Issue: Volume:91 Page:129373
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xiao Zili^ORCID,Yang Michael G.,Liu Chunjian,Sherwood Trevor^ORCID,Gilmore John L.^ORCID,Lin James,Li Peng,Wu Dauh-Rurng,Tokarski John^ORCID,Li Sha,Cheng Lihong,Xie Chunshan,Fan Jingsong,Dierks Elizabeth,Strnad Joann,Cvijic Mary Ellen,Khan Javed,Ruzanov Max,Galella Michael,Khandelwal Purnima,Dyckman Alaric J.^ORCID,Mathur Arvind^ORCID,Lombardo Louis J.,Macor John E,Carter Percy H.,Aranibar Nelly,Burke James R.,Weinstein David S.^ORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Mini Review: New treatments in psoriatic arthritis. Focus on the IL-23/17 axis;Sakkas;Front Pharmacol,2019

2. TYK2, prototype of a novel class of non-receptor tyrosine kinase genes;Firmbach-Kraft;Oncogene,1990

3. A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors;Sohn;J Immunol,2013

4. A heritable defect in IL-12 signaling in B10.Q/J mice. I. In vitro analysis;Ortmann;J Immunol,2001

5. Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis;Oyamada;J Immunol,2009

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP