Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors-Reference-Cited by-同舟云学术

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors

Published:2013-05 Issue:10 Volume:23 Page:3075-3080
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Xu Ying-zi,Yuan Shendong,Bowers Simeon,Hom Roy K.,Chan Wayman,Sham Hing L.,Zhu Yong L.,Beroza Paul,Pan Hu,Brecht Eric,Yao Nanhua,Lougheed Julie,Yan Jiangli,Tam Danny,Ren Zhao,Ruslim Lany,Bova Michael P.,Artis Dean R.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Global prevalence of dementia: a Delphi consensus study

2. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

3. Cellular mechanisms of beta -amyloid production and secretion

4. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

5. BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. One‐Pot Access to Tetrasubstituted 2‐Aminothiophenes via Regio‐ and Chemoselective Domino Reactions of Dithioesters with Fumaronitrile at Room Temperature;Advanced Synthesis & Catalysis;2023-08

2. Design, Synthesis and Evaluation of Catechol-Based Amyloid Beta Aggregation Inhibitors;HETEROCYCLES;2023

3. Recent synthetic advances in borylated pyrazoles;Tetrahedron Letters;2022-08

4. Cu-catalyzed [2 + 2 + 1] cascade annulation of vinyl iodonium salts with elemental sulfur/selenium for the modular synthesis of thiophenes and selenophenes;New Journal of Chemistry;2022

5. Synthesis and in vitro Anticancer Activity of Novel Heterocycles Utilizing Thiophene Incorporated Thioureido Substituent as Precursors;Acta Chimica Slovenica;2020-06-15