Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase-Reference-Cited by-同舟云学术

Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase

Published:2009-01 Issue:2 Volume:19 Page:424-427
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cee Victor J.,Cheng Alan C.,Romero Karina,Bellon Steve,Mohr Christopher,Whittington Douglas A.,Bak Annette,Bready James,Caenepeel Sean,Coxon Angela,Deak Holly L.,Fretland Jenne,Gu Yan,Hodous Brian L.,Huang Xin,Kim Joseph L.,Lin Jasmine,Long Alexander M.,Nguyen Hanh,Olivieri Philip R.,Patel Vinod F.,Wang Ling,Zhou Yihong,Hughes Paul,Geuns-Meyer Stephanie

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. Angiogenesis: an organizing principle for drug discovery?

2. Receptor tyrosine kinases as targets for inhibition of angiogenesis

3. Angiogenesis in cancer, vascular, rheumatoid and other disease

4. The biology of VEGF and its receptors

5. Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells

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