Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor-Reference-Cited by-同舟云学术

Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor

Published:2005-12 Issue:23 Volume:15 Page:5241-5246
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Macdonald Dwight,Mastracchio Anthony,Perrier Hélène,Dubé Daniel,Gallant Michel,Lacombe Patrick,Deschênes Denis,Roy Bruno,Scheigetz John,Bateman Kevin,Li Chun,Trimble Laird A.,Day Stephen,Chauret Nathalie,Nicoll-Griffith Deborah A.,Silva Jose M.,Huang Zheng,Laliberté France,Liu Susana,Ethier Diane,Pon Doug,Muise Eric,Boulet Louise,Chan Chi Chung,Styhler Angela,Charleson Stella,Mancini Joseph,Masson Paul,Claveau David,Nicholson Donald,Turner Mervyn,Young Robert N.,Girard Yves

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. The Multienzyme PDE4 Cyclic Adenosine Monophosphate–Specific Phosphodiesterase Family: Intracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant Actions

2. The Role of Phosphodiesterase Enzymes in Allergy and Asthma

3. Preferential Inhibition of T Helper 1, but Not T Helper 2, Cytokines in Vitro by L-826,141 [4-{2-(3,4-Bisdifluromethoxyphenyl)-2-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-phenyl]-ethyl}-3-methylpyridine-1-oxide], a Potent and Selective Phosphodiesterase 4 Inhibitor

4. The effects of phosphodiesterase type 4 inhibitors on tumour necrosis factor-α and leukotriene B4 in a novel human whole blood assay

5. Effects of a selective phosphodiesterase IV inhibitor (CDP-840) in a leukotriene-dependent non-human primate model of allergic asthma

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