Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5-Reference-Cited by-同舟云学术

Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5

Published:2010-10 Issue:19 Volume:20 Page:5718-5721
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Herbert Mark R.,Siegel Dana L.,Staszewski Lena,Cayanan Charmagne,Banerjee Urmi,Dhamija Sangeeta,Anderson Jennifer,Fan Amy,Wang Li,Rix Peter,Shiau Andrew K.,Rao Tadimeti S.,Noble Stewart A.,Heyman Richard A.,Bischoff Eric,Guha Mausumee,Kabakibi Ayman,Pinkerton Anthony B.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders

2. Identification of membrane-type receptor for bile acids (M-BAR)

3. A G Protein-coupled Receptor Responsive to Bile Acids

4. Endocrine functions of bile acids

5. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

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