DL -3- n -butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid- β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer’s therapy-Reference-Cited by-同舟云学术

DL -3- n -butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid- β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer’s therapy

Published:2017-02 Issue:4 Volume:27 Page:718-722
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Qiang Xiaoming,Li Yan,Yang Xia,Luo Li,Xu Rui,Zheng Yunxiaozhu,Cao Zhongcheng,Tan Zhenghuai,Deng Yong

Funder

Chinese National Natural Science Foundation

Research Fund for the Doctoral Program of Higher Education

National Science and Technology Major Project on “Key New Drug Creation and Manufacturing Program”

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: Synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine

2. Treatment of Alzheimer's disease; current status and new perspectives

3. Design, synthesis and biological evaluation of novel donepezil–coumarin hybrids as multi-target agents for the treatment of Alzheimer’s disease

4. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

5. Multifunctional 3-Schiff base-4-hydroxycoumarin derivatives with monoamine oxidase inhibition, anti-β-amyloid aggregation, metal chelation, antioxidant and neuroprotection properties against Alzheimer's disease

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