Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference19 articles.
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3. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation;Mujtaba;Mol Cell,2004
4. Bromodomain histone readers and cancer;Jain;J Mol Biol,2017
5. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription;Faiola;Mol Cell Biol,2005
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1. Bromodomain inhibitors and therapeutic applications;Current Opinion in Chemical Biology;2023-08
2. Targeting bromodomain-containing proteins: research advances of drug discovery;Molecular Biomedicine;2023-05-05
3. Recent Advances on Small-Molecule Bromodomain-Containing Histone Acetyltransferase Inhibitors;Journal of Medicinal Chemistry;2023-01-25
4. Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer;BMC Cancer;2022-06-08
5. Efficiently Constructing Tetrahydroquinolines through Cascade Radical Additions and Cyclizations under the Catalysis of Cu I;ChemistrySelect;2021-06-22
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