SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition-Reference-Cited by-同舟云学术

SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition

Published:2010-03 Issue:6 Volume:20 Page:1885-1889
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Rajapakse Hemaka A.,Nantermet Philippe G.,Selnick Harold G.,Barrow James C.,McGaughey Georgia B.,Munshi Sanjeev,Lindsley Stacey R.,Young Mary Beth,Ngo Phung L.,Katherine Holloway M.,Lai Ming-Tain,Espeseth Amy S.,Shi Xiao-Ping,Colussi Dennis,Pietrak Beth,Crouthamel Ming-Chih,Tugusheva Katherine,Huang Qian,Xu Min,Simon Adam J.,Kuo Lawrence,Hazuda Daria J.,Graham Samuel,Vacca Joseph P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Alzheimer's Disease and Parkinson's Disease

2. Alzheimer's Disease

3. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

4. Recent progress in the drug discovery of non-peptidic BACE1 inhibitors

5. Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1)

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The AQUA‐MER databases and aqueous speciation server: A web resource for multiscale modeling of mercury speciation;Journal of Computational Chemistry;2019-10-11

2. Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2;Journal of Medicinal Chemistry;2019-10-07

3. Correlation between molecular acidity (pKa) and vibrational spectroscopy;Journal of Molecular Modeling;2019-01-30

4. Quantum Chemical Calculation of pKas of Environmentally Relevant Functional Groups: Carboxylic Acids, Amines, and Thiols in Aqueous Solution;The Journal of Physical Chemistry A;2018-04-10

5. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation;Journal of Medicinal Chemistry;2018-04-03