Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP-Reference-Cited by-同舟云学术

Kinesin spindle protein (KSP) inhibitors. Part 2: The design, synthesis, and characterization of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Published:2006-04 Issue:7 Volume:16 Page:1775-1779
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Fraley Mark E.,Garbaccio Robert M.,Arrington Kenneth L.,Hoffman William F.,Tasber Edward S.,Coleman Paul J.,Buser Carolyn A.,Walsh Eileen S.,Hamilton Kelly,Fernandes Christine,Schaber Michael D.,Lobell Robert B.,Tao Weikang,South Victoria J.,Yan Youwei,Kuo Lawrence C.,Prueksaritanont Thomayant,Shu Cathy,Torrent Maricel,Heimbrook David C.,Kohl Nancy E.,Huber Hans E.,Hartman George D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference17 articles.

1. Motor Function in the Mitotic Spindle Minireview

2. Microtubule motors in mitosis

3. Microtubule motors in spindle and chromosome motility

4. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

5. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

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