Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: Variations on the 1H-pyrimidin-2-one theme

Author:

Geneste Hervé,Amberg Wilhelm,Backfisch Gisela,Beyerbach Armin,Braje Wilfried M.,Delzer Jürgen,Haupt Andreas,Hutchins Charles W.,King Linda L.,Sauer Daryl R.,Unger Liliane,Wernet Wolfgang

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference10 articles.

1. Unger, L.; Ladona, F. J. G.; Wernet, W.; Sokoloff, P.; Wicke, K. M.; Gross, G. Poster, 32nd Annual Meeting of the Society for Neuroscience, Orlando, FL, November 2–7, 2002; Society for Neuroscience: Washington, DC, 2002; Abs 894.5. Drescher, K. U.; Ladona, F. J. G., Teschendorf, H. J.; Traut, M.; Unger, L.; Wicke, K. M.; Weddige, F. K.; Freeman, A. S.; Gross, G. Poster, 32nd Annual Meeting of the Society for Neuroscience, Orlando, FL, November 2–7, 2002; Society for Neuroscience: Washington, DC, 2002; Abs 894.6.

2. Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: 1H-Pyrimidin-2-one derivatives

3. Synthesis and SAR of highly potent and selective dopamine D3-receptor antagonists: Quinolin(di)one and benzazepin(di)one derivatives

4. Ligandless palladium catalyzed reactions of arylboronic acids and sodium tetraphenylborate with aryl halides in aqueous media

5. The dopamine D3 receptor partial agonist, BP 897, is an antagonist at human dopamine D3 receptors and at rat somatodendritic dopamine D3 receptors

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