Discovery and synthesis of a novel series of quinoline-based thrombin receptor (PAR-1) antagonists

Author:

Clasby Martin C.,Chackalamannil Samuel,Czarniecki Michael,Doller Dario,Eagen Keith,Greenlee William J.,Lin Yan,Tsai Hsingan,Xia Yan,Ahn Ho-Sam,Agans-Fantuzzi Jacqueline,Boykow George,Chintala Madhu,Foster Carolyn,Bryant Matthew,Lau Janice

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Coleman, R. W.; Marder, V. J.; Salzman, E. W.; Hirsh, J. In Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 1994, pp 3–17.

2. The coagulation cascade: initiation, maintenance, and regulation

3. How the protease thrombin talks to cells

4. Coughlin, S. R. Protease-Activated Receptors in the Cardiovascular System. Cold Spring Harb. Symp. Quant. Biol. 2002, 67, 197.

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