Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification-Reference-Cited by-同舟云学术

Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification

Published:2019-11 Issue:22 Volume:29 Page:126720
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Liao Yixian,Jia Xiuhua,Tang Yongmei,Li Sumei,Zang Yipeng,Wang Lei,Cui Zi-Ning,Song Gaopeng

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

National Key Project for Basic Research of China

973 Program

Natural Science Foundation of Guangdong Province

Science & Technology Project of Guangzhou

Natural Science Foundation of Guizhou Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference29 articles.

1. Keynote review: Phosphodiesterase-4 as a therapeutic target

2. Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

3. Cyclic AMP: a selective modulator of NF-κB action

4. Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

5. Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration

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