Synthesis of 2-,4,-6-, and/or 7-substituted quinoline derivatives as human dihydroorotate dehydrogenase (hDHODH) inhibitors and anticancer agents: 3D QSAR-assisted design

Author:

Vyas Vivek K.,Qureshi Gulamnizami,Oza Drashti,Patel Hardik,Parmar Krupali,Patel Palak,Ghate Manjunath D.

Funder

Nirma University

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. The dihydroorotate dehydrogenases: past and present;Reis;Arch Biochem Biophys,2017

2. Recent developments in the medicinal chemistry and therapeutic potential of dihydroorotate dehydrogenase (DHODH) Inhibitors;Vyas;Mini-Reviews Med Chem,2011

3. Pyrimidine pathways in health and disease;Löffler;Trends Mol Med,2005

4. Correction: a DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (Nature Communications (2018) DOI: 10.1038/s41467-018-03441-3);Ladds;Nat Commun,2018

5. Mechanism of action of the novel anticancer agent 6-Fluoro-2-(2’-fluoro-1,1’-biphenyl-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis;Chen;Cancer Res,1986

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