Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors-Reference-Cited by-同舟云学术

Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF–FVIIa inhibitors

Published:2013-03 Issue:6 Volume:23 Page:1604-1607
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Zhang Xiaojun,Glunz Peter W.,Jiang Wen,Schmitt Aaron,Newman Makenzie,Barbera Frank A.,Bozarth Jeffery M.,Rendina Alan R.,Wei Anzhi,Wen Xiao,Rossi Karen A.,Luettgen Joseph M.,Wong Pancras C.,Knabb Robert M.,Wexler Ruth R.,Scott Priestley E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. The inhibitors of the tissue factor:factor VII pathway

2. Tissue factor – a therapeutic target for thrombotic disorders

3. The antithrombotic and anti-inflammatory effects of BCX-3607, a small molecule tissue factor/factor VIIa inhibitor

4. Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model

5. Administration of a small molecule tissue factor/Factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time

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2. Screening of a Library for Factor VIIa Inhibitors;Letters in Drug Design & Discovery;2021-12-07

3. One-Pot Multicomponent Synthesis and Anticancer Activity of 1,3-Cyclopentathiazine and Pyrimidothiazine Derivatives;Russian Journal of Organic Chemistry;2020-05

4. Discovery of a New Pyrazinone Natural Product by Genome Mining;Chinese Journal of Organic Chemistry;2016

5. Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors;Journal of Medicinal Chemistry;2015-07-28