Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity-Reference-Cited by-同舟云学术

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity

Published:2010-11 Issue:22 Volume:20 Page:6797-6801
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Elliott Richard L.,Cameron Kimberly O.,Chin Janice E.,Bartlett Jeremy A.,Beretta Elena E.,Chen Yue,Jardine Paul Da Silva,Dubins Jeffrey S.,Gillaspy Melissa L.,Hargrove Diane M.,Kalgutkar Amit S.,LaFlamme Janet A.,Lame Mary E.,Martin Kelly A.,Maurer Tristan S.,Nardone Nancy A.,Oliver Robert M.,Scott Dennis O.,Sun Dexue,Swick Andrew G.,Trebino Catherine E.,Zhang Yingxin

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. Role of cholecystokinin in appetite control and body weight regulation

2. Cholecystokinin bioactivity in human plasma. Molecular forms, responses to feeding, and relationship to gallbladder contraction.

3. Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats

4. Cholecystokinin antagonists: Pharmacological and therapeutic potential

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