Design, synthesis, and biological evaluation of novel analogues of archazolid: A highly potent simplified V-ATPase inhibitor

Author:

Menche Dirk,Hassfeld Jorma,Sasse Florenz,Huss Markus,Wieczorek Helmut

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. Höfle, G.; Reichenbach, H.; Sasse, F.; Steinmetz, H. German Patent DE 41 42 951 C1, 1993.

2. Archazolids, New Cytotoxic Macrolactones from Archangium gephyra (Myxobacteria) Production, Isolation, Physico-chemical and Biological Properties

3. Very recently, the first archazolid glycoside has been isolated from the myxobacterium Cystobacter violaceus: Menche, D.; Hassfeld, J.; Steinmetz, H.; Huss, M.; Wieczorek, H.; Sasse, F., Eur. J. Org. Chem., in press.

4. Animal plasma membrane energization by proton-motive V-ATPases

5. The vacuolar (H+)-ATPases — nature's most versatile proton pumps

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