Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation-Reference-Cited by-同舟云学术

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Published:2007-03 Issue:6 Volume:17 Page:1788-1792
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Stauffer Shaun R.,Stanton Matthew G.,Gregro Alison R.,Steinbeiser Melissa A.,Shaffer Jennifer R.,Nantermet Philippe G.,Barrow James C.,Rittle Kenneth E.,Collusi Dennis,Espeseth Amy S.,Lai Ming-Tain,Pietrak Beth L.,Holloway M. Katharine,McGaughey Georgia B.,Munshi Sanjeev K.,Hochman Jerome H.,Simon Adam J.,Selnick Harold G.,Graham Samuel L.,Vacca Joseph P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Structure and Mechanism of the Pepsin-Like Family of Aspartic Peptidases

2. The Aβ Hypothesis: Leading Us to Rationally-Designed Therapeutic Strategies for the Treatment or Prevention of Alzheimer Disease

3. Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation

4. BACE1 is the major β-secretase for generation of Aβ peptides by neurons

5. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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