Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction-Reference-Cited by-同舟云学术

Isoindolinone-based inhibitors of the MDM2–p53 protein–protein interaction

Published:2005-03 Issue:5 Volume:15 Page:1515-1520
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hardcastle Ian R.,Ahmed Shafiq U.,Atkins Helen,Calvert A. Hilary,Curtin Nicola J.,Farnie Gillian,Golding Bernard T.,Griffin Roger J.,Guyenne Sabrina,Hutton Claire,Källblad Per,Kemp Stuart J.,Kitching Martin S.,Newell David R.,Norbedo Stefano,Northen Julian S.,Reid Rebecca J.,Saravanan K.,Willems Henriëtte M.G.,Lunec John

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. p53, guardian of the genome

2. Live or let die: the cell's response to p53

3. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

4. Mdm2 association with p53 targets its ubiquitination

5. Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

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